Quantitative structural mechanobiology of platelet-driven blood clot contraction
نویسندگان
چکیده
منابع مشابه
Similarities between platelet contraction and cellular motility during mitosis: role of platelet microtubules in clot retraction.
The effects of inhibitors of mitosis, energy metabolism and protein synthesis on clot retraction were investigated. The results show that (1) Incubation of colchicine (0-01-0-1 mM) with platelet-rich plasma (PRP) inhibits the subsequent retraction of clots derived from diluted PRP. (2) Inhibition of clot retraction by high concentrations of colchicine (up to 40 mM) can be overcome by increasing...
متن کاملKinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood Running Title: Kinetics and mechanics of blood clot contraction
School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Kazan Federal University, Kazan, Russia; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; HemaCore Ltd., Mosco...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/s41467-017-00885-x